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Chapter 8 Superficial and deep perivascular inflammatory dermatoses Chronic superficial dermatitis 259 Toxic erythema 261 Erythema annulare centrifugum 261 Erythema gyratum repens 263 Lymphocytic infiltrate of the skin 264 Reticular erythematous mucinosis 265 Polymorphous light eruption 267 Tumid lupus erythematosus 269 Perniosis 270 Chilblain lupus erythematosus 272 Pigmented purpuric PERIVASCULAR INFILTRATES See DX Path for details of the conditions below Sometimes when you look at a slide the first thing you notice is that there is an infiltrate around vessels which can be superficial or deep or a combination of both. Perivascular neutrophils and lymphocytes. Lupus erythematosus General. A group of skin diseases - includes: The systemic disease, systemic lupus erythematosus, that typically has multi-organ involvement. Microscopic. Features - classic: Lymphocytic interface dermatitis.

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In allergic/contact dermatitis and atopic dermatitis, eosinophils may be present in the dermis and epidermis (eosinophilic spongiosis). Polymorphic light eruption (PMLE) is a form of photosensitivity, which usually occurs in younger females.It is more common in patients who receive only intermittent sun exposure and typically consists of crops of papules, vesicles or plaques. Predominantly, a superficial perivascular lymphocytic infiltrate, extravasation of erythrocytes, and focal interface changes characterized DRESS cases. Less frequently, histopathology revealed the presence of necrotic keratinocytes; surprisingly, only in 2 cases the presence of rare dermal eosinophils was detected, even if all the patients had significant peripheral eosinophilia. Id reaction (Autoeczematization) •Dissemination of a previously localized ‘eczematous’ process such as fungal infection or stasis dermatitis •Commonly seen as a reaction to foods, look at the feet and nails for fungus. An id reaction is an eczematous skin reaction that develops in response to a distant unknown antigen.


A few basal apoptotic keratinocytes are sometimes present. The vessels have a regular profile. Some lesions show nodular collection of blood vessels with perivascular inflammation.

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It is the breakdown of the red blood cells that leaves iron pigment behind that gives both the clinical picture and the histological picture. If you look carefully at the blood vessels in pigmented purpuric eruption, there may be a bit of endothelial cell swelling and some perivascular thickening. DHR is a perivascular lymphocytic dermatitis with eosinophils involving the papillary and upper reticular dermis and minimal, if any, primary epidermal alteration. The term DHR does not represent any known clinical disorder; rather, it corresponds to many clinical disorders.

In contrast, the chronic lichenified AP lesions are associated with marked hyperkeratosis, acanthosis, elongation of the rete ridges, and tissue repair. Special studies of interstitial granulomatous dermatitis. Immunofluorescence may be positive for IgM, C3 and fibrinogen in dermal blood vessels.. Differential diagnosis of interstitial granulomatous dermatitis. Leucocytoclastic vasculitis: Neutrophils and dust in interstitial granulomatous dermatitis are more widely distributed throughout the dermis in addition to around vessels. To subscribe to Journal of Clinical Pathology go to: Downloaded from jcp.bmj.com on December 21, 2009 - Published by group.bmj.com. Drug-induced cutaneous pathology perivascular dermatitis, nodular and diffuse dermatitis, vesiculobullous lesions, pustular eruptions, sclerodermoid Perioral dermatitis is a relatively common inflammatory disorder of facial skin, often appearing in patients with rosacea, but with less inflammation.
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Signalment (JPC # 21474-29): Dog, breed not specified. HISTORY: This dog had bilaterally symmetrical, rugose thickening, lichenification, and gray-black hyperpigmentation of the axillary skin. HISTOPATHOLOGIC DESCRIPTION: Haired skin, axilla (per contributor): Diffusely, the epidermis is moderately to markedly hyperplastic 2006-01-01 Luz Fonacier, Mark Boguniewicz, in Pediatric Allergy: Principles and Practice (Third Edition), 2016. Spectrum of Contact Dermatitis. Contact dermatitis is traditionally divided into ICD, accounting for 80%, and ACD, accounting for 20% of these reactions.

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SEPTEMBER 2019. I-M06 . Signalment (JPC # 21474-29): Dog, breed not specified.

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Perivascular lymphocytic infiltrate. Perivascular lymphocytic infiltrate refers to inflammation centred around the small vessels in the skin. It is usually a lymphocytic or lymphohistiocytic inflammatory infiltrate, without evidence of vascular damage/ death (vasculitis). Pigment incontinence Background: Psoriasiform dermatitis is a frequently encountered terminology in a wide variety of inflammatory dermatoses. It often poses challenges to both dermatologists and pathologists alike. Background The pigmented purpuric dermatoses are a group of chronic diseases of mostly unknown etiology that have a very distinctive clinical appearance. They are characterized by extravasation of The reaction most likely to give intraepidermal vesicles is in fact an allergic contact dermatitis, but as I have already said drugs such as thiazide diuretics and calcium channel blockers can also cause spongiotic drug reactions.

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They are characterized by extravasation of The reaction most likely to give intraepidermal vesicles is in fact an allergic contact dermatitis, but as I have already said drugs such as thiazide diuretics and calcium channel blockers can also cause spongiotic drug reactions.

Not infrequently, however, contact dermatitis presents with A 71-year-old man expires in a nursing home and an autopsy is performed. At autopsy, he is found to have a strangulated segment of jejunum within an incisional hernia with resulting sepsis. In addition, an enlarged thymus weighing 30 grams is identified. Representative tissue is obtained from the… Factitious dermatitis is a self-inflicted injury of the skin that presents as a bizarre eruption (often ulcerated) with linear and geometric outlines. The patient's history is vague and unclear. The diagnosis is made when the clinician has a high index of suspicion in a patient who has apparent secondary gain from perpetuating the condition.